Skin detox and anti-aging benefits for urban-stressed skin
Urban skin is continuously exposed to UV, pollution, city stress and micro-inflammation. Over time, this can accelerate premature aging and visibly affect skin quality, contributing to dullness, uneven complexion, rougher texture and wrinkles.
CYNAGE™ is Bionap’s natural cosmetic active ingredient for urban anti-pollution skincare, developed to deliver targeted skin detox and anti-aging benefits for mature, sensitive and urban-stressed skin.

Standardized in chlorogenic acid and derived from artichoke leaves, CYNAGE™ is designed to help skin better respond to environmental aggressors while improving visible skin appearance.
A targeted active for urban skin protection
Exposure to pollution and environmental stress can weaken the skin’s natural defense systems and accelerate visible aging processes. CYNAGE™ supports the skin’s ability to cope with these stressors by reinforcing endogenous defense mechanisms linked to oxidative stress and inflammation.
By combining protective support with visible cosmetic outcomes, CYNAGE™ enables formulators to develop products that respond to both environmental exposure and skin appearance concerns.

Clinical performance on urban-stressed skin
CYNAGE™ is supported by a 28-day placebo-controlled hemi-face clinical study conducted on subjects exposed to urban environmental stressors and presenting visible signs of skin aging and dullness.
CYNAGE™ vs Placebo:
- Increases skin radiance: +50%
- Increases skin smoothness: +120%
- Reduces the wrinkles depth: -188%
- Decreases significantly photo-pollution-induced skin inflammation
- It is effective in increasing skin antioxidant properties after exposure to sun radiation and air pollution.
- Determines an improvement in the aesthetic appearance of face skin, making it “younger looking” (-2,3 years after 28 days of treatment)
Applied at 1.5% in a cosmetic cream, twice daily, CYNAGE™ delivered visible and measurable improvements in skin appearance, including:
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Formulation versatility
CYNAGE™ is suitable for a wide range of personal care formulations and can be incorporated into products positioned around urban defense and anti-aging performance, including:
- anti-pollution day creams
- urban defense serums
- skin detox treatments
- anti-aging facial care
- radiance-enhancing formulations
- skincare for sensitive or stressed skin
Its compatibility with common production processes allows formulators to integrate this active ingredient into multiple product formats.
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