Modulation of the cross-talk in melanogenesis: a novel multifunctional peptide

Pigmentation issues are one of the most common skincare concerns among consumers of all ages and gender. In this context, we present a smartly-designed peptide, D17ChAH, a novel acetyl hexapeptide-1, which was used to address skin pigmentation through a multi-target mechanism of action. The peptide tackles specific cell-to-cell communication network between fibroblasts, melanocytes and keratinocytes by significantly decreasing production of Stem Cell Factor (KITLG/SCF) protein in both, HDFa and HEKa. KITLG/SCF modulation leads to a decrease of the paracrine communication, reducing the number, size and dendrites of melanocytes. Finally, the clinical efficacy was performed on Asian volunteers, where we were able to conclude that novel acetyl hexapeptide-1 shows excellent skin lightening activity while highlighting the natural glow and boosting the skin antioxidation and hydration.