INTRODUCTION
Skin stress, results in multiple physiological impacts leading to a variety of skin disorders. A stress response is the activation of the endocrine, neurologic, and immune systems triggering a cascade of impacts, that are both systemic and cutaneous. Both the sympathetic nervous system and the hypothalamic-pituitary-adrenal system participate in the stress response (1). The consequential release of cortisol, catecholamines and neuropeptides have multiple clinical effects including an increase in skin inflammation, impaired skin barrier function, impaired wound healing, and suppressed immunity (2).
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